Publications

38. Faridi MH, Khan SQ, Zhao W, Lee HW, Altintas MM, Zhang K, Kumar V, Armstrong AR, Carmona-Rivera C, Dorschner JM, Schnaith AM, Li X, Ghodke-Puranik Y, Moore E, Purmalek M, Irizarry-Caro J, Zhang T, Day R, Stoub D, Hoffmann V, Khaliqdina SJ, Bhargava P, Santander AM, Torroella-Kouri M, Issac B, Cimbaluk DJ, Zloza A, Prabhakar R, Deep S, Jolly M, Koh KH, Reichner JS, Bradshaw EM, Chen J, Moita LF, Yuen PS, Li Tsai W, Singh B, Reiser J, Nath SK, Niewold TB, Vazquez-Padron RI, Kaplan MJ and Gupta V, CD11b activation suppresses TLR-dependent inflammation and autoimmunity in systemic lupus erythematosus, J Clin Invest. 2017, Mar 6. DOI: 10.1172/JCI88442.
Online link

37. Hahm E, Wei C, Fernandez I, Li J, Tardi N, Tracy M, Wadhwani S, Cao Y, Peev V, Zloza A, Lusciks J, Hayek SS, O’Connor C, Bitzer M, Gupta V, Sanja Sever, David B Sykes, David T Scadden and Jochen Reiser, Bone marrow-derived immature myeloid cells are a main source of circulating suPAR contributing to proteinuric kidney disease, Nature Medicine 2017, 23, 100–106. DOI: 10.1038/nm.4242.
Online link

36. Lee HW, Khan SQ, Khaliqdina S, Altintas MM, Grahammer F, Zhao JL, Koh K, Tardi NJ, Faridi MH, Geraghty T, Cimbaluk DJ, Susztak K, Moita LF, Baltimore D, Tharaux PL, Huber TB, Kretzler M, Bitzer M, Reiser J and Gupta V, Absence of miR-146a in podocytes increases risk of diabetic glomerulopathy via upregulation of erbb4 and notch-1, J Biol Chem. 2016 Dec 2. PMID: 27913625. DOI: 10.1074/jbc.M116.753822.
Online link

35. Johnson CM, O’Brien XM, Byrd AS, Parisi VE, Loosely AJ, Li W, Witt H, Faridi HM, Lefort CT, Gupta V, Kim M, and Reichner JS, Integrin Cross-Talk Regulates the Human Neutrophil Response to Fungal β-Glucan in the Context of the Extracellular Matrix: A Prominent Role for VLA3 in the Antifungal Response, J Immunol. 2016 Nov 16. PMID: 27852744. DOI: 10.4049/jimmunol.1502381.
Online link

34. Gupta V, and Reiser J, Stop that podocyte! American Journal of Physiology-Renal Physiology. 2016 Oct 19. PMID: 27760773. DOI: 10.1152/ajprenal.00499.2016.
Online link

33. Gu C, Lee HW, Garborcauskas G, Reiser J, Gupta V, and Sever S, Dynamin Autonomously Regulates Podocyte Focal Adhesion Maturation, Journal of the American Society of Nephrology. 2016 Jul 18. PMID: 27432739. DOI: 10.1681/ASN.2016010008.
Online link

32. Jagarapu J, Kelchtermans J, Rong M, Chen S, Hehre D, Hummler S, Faridi MH, Gupta V, and Wu, S, Leukadherin-1 Attenuates Hyperoxia-induced Lung Injury in Neonatal Rats, Am J Respir Cell Mol Biol. 2015 Apr 24. [Epub ahead of print]. PMID: 25909334. DOI: 10.1165/rcmb.2014-0422OC.
Online link

31. Lee HW, Khan SQ, Faridi MH, Wei C, Tardi NJ, Altintas MM, Elshabrawy HA, Mangos S, Quick KL, Sever S, Reiser J and Gupta V, A Podocyte-Based Automated Screening Assay Identifies Protective Small Molecules, Journal of the American Society of Nephrology. 2015 Apr 9, 2015. pii: ASN.2014090859. [Epub ahead of print]. PMID: 25858967. doi: 10.1681/ASN.2014090859.
Online link

30. Khan SQ, Guo L, Cimbaluk DJ, Elshabrawy H, Faridi MH, Jolly M, George JF, Agarwal A and Gupta V, A Small Molecule β2 Integrin Agonist Improves Chronic Kidney Allograft Survival by Reducing Leukocyte Recruitment and Accompanying Vasculopathy, Front. Med., 2014 12 Nov 2014. doi: 10.3389/fmed.2014.00045
Online link

29. Gupta V and Reiser J, MicroRNAs: A Macroview Into Focal Segmental Glomerulosclerosis,  Am J Kidney Dis. 2015 Feb;65(2):206-8. doi:10.1053/j.ajkd.2014.11.003
Online link

28. Rodriguez-Menocal L, Faridi MH, Martinez L, Shehadeh LA, Duque JC, Wei Y, Mesa A, Pena A, Gupta V, Pham SM and Vazquez-Padron RI, Macrophage-derived IL-18 and increased fibrinogen deposition are age-related inflammatory signatures of vascular remodeling, American Journal of Physiology – Heart and Circulatory Physiology, 2014 March 2014, Vol. 306, no. 5, H641-H653. doi:10.1152/ajpheart.00641.2013.
Online link

27. Cascão R, Vidal B, Raquel H, Neves-Costa A, Figueiredo N, Gupta V, Fonseca JE and Moita LF, Potent Anti-Inflammatory and Anti-Proliferative Effects of Gambogic Acid in a Rat Model of Antigen-Induced Arthritis, Mediators of Inflammation, 2014 Jan, Volume 2014 (2014), Article ID 195327. doi:10.1155/2014/195327
Online link

26. Celik E, Faridi MH, Kumar V, Deep S, Moy VT and Gupta V, Agonist leukadherin-1 increases CD11b/CD18 dependent adhesion via membrane tethers, Biophysical Journal, 2013 Dec, Volume 105, Issue 11, 2517-2527. doi:10.1016/j.bpj.2013.10.020.
Online link

25. Weston W, Gupta V, Adkins R, Jurecic R, New therapeutic approaches for protecting hematopoietic stem cells in aplastic anemia, Immunol Res, 2013 Dec;57(1-3):34-43. doi:10.1007/s12026-013-8449-0.
Online link

24. Figueiredo N, Chora A, Raquel H, Pejanovic N, Pereira P, Hartleben B, Neves-Costa A, Moita C, Pedroso D, Pinto A, Marques S, Faridi H, Costa P, Gozzelino R, Zhao JL, Soares MP, Gama-Carvalho M, Martinez J, Zhang Q, Döring G, Grompe M, Simas JP, Huber TB, Baltimore D, Gupta V, Green DR, Farreira JA, Moita LF, Anthracyclins induce autophagy-mediated protection from severe sepsis, Immunity, 2013 Nov 14;39(5):874-84. doi:10.1016/j.immuni.2013.08.039.
Online link

23. Yu CC, Fornoni A, Weins A, Hakroush S, Maiguel D, Sageshima J, Chen L, Ciancio G, Faridi MH, Behr D, Campbell KN, Chang JM, Chen HC,Oh J, Faul C, Arnaout MA, Fiorina P, Gupta V, Greka A, Burke G, Mundel P, Abatacept in B7-1 Positive Proteinuric Kidney Disease, New England Journal of Medicine, 2013 Nov 8. doi:10.1056/NEJMoa1304572.
Online link

22. Bhat V, Olenick MB, Schuchardt BJ, Mikles DC, Deegan BJ, McDonald CB, Seldeen KL, Kurouski D, Faridi MH, Shareef MM, Gupta V, Lednev IK, Farooq A, Heat-induced fibrillation of BclXL apoptotic repressor, Biophys Chem, 2013 Sep;179:12-25. doi: 10.1016/j.bpc.2013.04.002.
Online link

21. Faridi MH, Altintas MM, Gomez C, Duque JC, Vazquez-Padron RI, Gupta V, Small molecule agonists of integrin CD11b/CD18 do not induce global conformational changes and are significantly better than activating antibodies in reducing vascular injury, Biochimica et Biophysica Acta, 2013 Jun;1830(6):3696-710. doi: 10.1016/j.bbagen.2013.02.018.
Online link

20. Reed RH, Jain M, Lee K, Kandimalla ER, Faridi MH, Buyon JP, Gupta V, Clancy RM, Complement receptor 3 influences Toll-like receptor 7/8 dependent inflammation: implications for autoimmune diseases characterized by antibody reactivity to ribonucleoproteins, J Biol Chem, 2013. Mar 29;288(13):9077-83. doi: 10.1074/jbc.M112.403303.
Online link

19. Cascão R, Vidal B, Raquel H, Neves-Costa A, Figueiredo N, Gupta V, Fonseca JE, Moita LF, Effective treatment of rat adjuvant-induced arthritis by celastrol, Autoimmun Rev, 2012. Oct;11(12):856-62. doi: 10.1016/j.autrev.2012.02.022. Epub 2012 Mar 3.

18. Maiguel D, Faridi MH, Wei C, Kuwano Y, Balla KM, Hernandez D, Barth CJ, Lugo G, Donnelly M, Nayer A, Moita LF, Schürer S, Traver D, Ruiz P, Vazquez-Padron RI, Ley K, Reiser J, Gupta V, Small molecule-mediated activation of the integrin CD11b/CD18 reduces inflammatory disease, Science Signaling, 2011 Sep 6;4(189):ra57. PMID: 21900205
Article link

This work was featured in a Highlight in Nature Reviews in Immunology, 11, 638 (October 2011) and in a Highlight in Acta Pharmacologica Sinica (2011) 32: 1309–1310.

17. Wei C, El Hindi S, Li J, Fornoni A, Goes N, Sageshima J, Maiguel D, Karumanchi SA, Yap HK, Saleem M, Zhang Q, Nikolic B, Chaudhuri A, Daftarian P, Salido E, Torres A, Salifu M, Sarwal MM, Schaefer F, Morath C, Schwenger V, Zeier M, Gupta V, Roth D, Rastaldi MP, Burke G, Ruiz P, Reiser J., Circulating urokinase receptor as a cause of focal segmental glomerulosclerosis. Nature Medicine, 2011 Jul 31;17(8):952-60. doi: 10.1038/nm.2411. PMID: 21804539
Online link

This work was featured as a Cover article and in a Highlight in the same issue of Nature Medicine.

16. Faridi MH, Maiguel D, Brown BT, Suyama E, Barth CJ, Hedrick M, Vasile S, Sergienko E, Schürer S, Gupta V, High-throughput screening based identification of small molecule antagonists of integrin CD11b/CD18 ligand binding, Biochem Biophys Res Commun, 2010, Mar 26;394(1):194-9. Epub 2010 Feb 25. PMID: 20188705.
File link

15. Reiser J, Gupta V, Kistler AD. Toward the development of podocyte-specific drugs, Kidney International 2010 Apr;77(8):662-8. Epub 2010 Feb 3. PMID: 20130528. Online link

14. Faridi MH, Maiguel D, Barth CJ, Stoub D, Day R, Schürer S, Gupta V, Identification of novel agonists of the integrin CD11b/CD18, Bioorg Med Chem Lett, 2009 Dec 15;19(24):6902. NIHMS154324. File link

13. Qureshi AH, Chaoji V, Maiguel D, Faridi MH, Barth CJ, Salem SM, Singhal M, Stoub D, Krastins B, Ogihara M, Zaki MJ, Gupta V, Proteomic and phospho-proteomic profile of human platelets in basal, resting state: insights into integrin signaling, PLoS One, 2009 Oct 27;4(1):e7627. File link

12. Banerjee A., Sergienko E., Vasile S., Gupta V., Vuori K. and Wipf P., Triple Hybrids of Steroids, Spiroketals, and Oligopeptides as New Biomolecular Chimeras, Organic Letters, 2009 Jan 1;11(1):65. File link

11. Gupta V., Alonso J.-L., Sugimori T., Issafi M., Xiong J.-P. and Arnaout M. A., Role of the beta-subunit arginine/lysine finger in integrin heterodimer formation and function, Journal of Immunology, 2008 Mar 1;180(5):3613. File link

10. Wei C., Möller C.C., Altintas M.M., Li J., Schwarz K., Zacchigna S., Xie L., Henger A., Schmid H., Rastaldi M.P., Cowan P., Kretzler M., Parrilla R., Bendayan M., Gupta V., Nikolic B., Kalluri R., Carmeliet P., Mundel P. and Reiser J., Modification of kidney barrier function by the urokinase receptor, Nature Medicine, 2008 Jan;14(1):55-63. Epub 2007 Dec 16. File link

9. Park, J.Y., Arnaout, M.A. and Gupta V., A simple, no-wash cell-adhesion based high throughput assay for the discovery of small molecule regulators of the integrin CD11b/CD18, Journal of Biomolecular Screening, 2007 Apr;12(3):406-17. File link

8. Gupta V., Gylling A., Alonso, J.-L., Sugimori T., Ianakiev, P., Xiong J.-P. and Arnaout M. A.,The β-tail domain (βTD) regulates physiologic ligand binding to integrin CD11b/CD18, Blood, 2007 Apr 15;109(8):3513-20. Epub 2006 Dec 14 (DOI 10.1182/blood-2005-11-056689). File link

This work was featured in a Highlight in the same issue of Blood.

7. Gupta* V., Cherkassky A., Chatis P., Joseph R., Johnson A. J., Erickson T. and Dimeo J., Directly labeled mRNA produces highly precise and unbiased differential gene expression data, Nucleic Acids Research, 2003, 31, e13. File link

6. Werner MH, Nagata T, Gupta V, Goger M, Chait BT, Sâli A, Kim WY, Shigesada K, Ito Y. Molecular insights into the origin of the acute human leukemias revealed from the three-dimensional structure and sub-cellular localization of AML1, Clinical Cancer Res, 1999, 5, 3780S.

5. Werner M. H., Gupta V., Lambert L.J. and Nagata T., Uniform 13C/15N-labeling of DNA by tandem repeat amplification, Methods in Enzymology, 2001, 338, 283-304. File link

4. Nagata* T., Gupta* V., Sorce D., Kim W-Y., Sâli A., Chait B. T., Shigesada K., Ito Y. and Werner M. H., Immunoglobulin-motif DNA recognition and heterodimerization for the PEBP2/CBF Runt-domain, Nature Structural Biology, 1999, 615-619. File link

3. Goger* M., Gupta* V., Kim W-Y., Shigesada K., Ito Y. and Werner M. H. ,Molecular insights into PEBP2/CBF-SMMHC associated acute leukemias revealed from the three-dimensional structure of PEBP2/CBF beta, Nature Structural Biology, 1999, 620-623. File link

2. Gupta V. and Kool E. T. A Novel Self-Cleaving DNA Nucleoside, Chemical Communications, 1997, 1425-26. File link

1. Jayaram B., Aneja N., Rajsekaran E., Arora V., Das A., Ranganathan V. and Gupta V., Modeling DNA in Aqueous Solution, Journal of Scientific and Industrial Research, 1994, 53 (2), 88-105.

Additional details on some of the PUBLICATIONS.

Others Publications

8. Cheng, Q., Ogihara, M., and Gupta, V., Learning condition-dependent dynamical PPI networks from conflict-sensitive phosphorylation dynamics, In Proceedings of the IEEE Conference on Biomedicine and Computational Biology (IEEE-BIBM), 2011. B459. Online link

7. Jain, Manish, Amato, Michael, Buyon, Jill P., Gupta V, Clancy, Robert M.; A Novel CR3 Agonist Attenuates Pro-Inflammatory Signaling in Subjects with Common and Variant ITGAM Polymorphism, rs1143679. Arthritis Rheum 2011;63 Suppl 10 :1675.

6. Cascão R, Vidal B, Raquel H, Neves-Costa A, Figueiredo N, Gupta V, Fonseca JE, Moita LF. Drugs that simultaneously down-regulate IL-1b and TNF secretion significantly reduce inflammation in a rat model of antigen-induced arthritis, Journal of Translational Medicine 2011, 9(Suppl 2):P21.

5. Cheng, Q., Gupta, V., and Ogihara, M., Inferring conflicting phosphorylation dynamics, In Proceedings of the ACM Conference on Computational Biology and Biomedicine (ACM-BCB), 2011. Online link

4. Dony Maiguel; Mohd Hafeez Faridi; Roberto Vazquez-Padron; Vineet Gupta Novel Small Molecule Agonists of Integrin Cd11b/cd18 Reduce Leukocyte Migration and Post Injury Neointimal Hyperplasia, Circulation 2010; 122: A16106.

3. Gupta V., Parthasarathsy S. and Zaki M. J., Arithmetic and Logic Operations with DNA, Proceedings of the 3rd DIMACS Workshop on DNA Based Computers 1997, 212-220. File link

2. Gupta V. Studies Aimed at Controlled Chemical Cleavage of DNA. Thesis, 1997 University Of Rochester, 1997.

1. Gupta V. Computer Modeling and Theoretical Studies of Drug-DNA Interactions. Thesis, 1992 Indian institute of Technology, Delhi; 1992.

Published Patents and Patent Applications

1. Gupta V. and Werner M. H., Methods for Preparing Polynucleotide Sequences and Uses Thereof, Patent number US6194179, 2001. Download file.

2. Jacobs A. A., Gupta V. and Nikolic B., Clinically Intelligent Diagnostic Devices and Methods, Patent number US6905816. Download file.

3. Chui B., Elghanian R. E., Gupta V. et al., P450 Single Nucleotide Polymorphism Biochip Analysis, Patent Number US6986992. Download file.

4. Brush, C.K. and Gupta V., Post-Synthetic Labeling of Nucleic Acids, Assays Using Nucleic Acids that are Labeled Post-Synthetically, Single Nucleotide Polymorphism Detection, and Associated Compounds and Microarrays, Patent Number US7223538.

5. Jacobs A. A., Gupta V. and Nikolic B., Clinically Intelligent Diagnostic Devices and Methods, Patent Number US7566533.

6. Jacobs A. A., Gupta V. and Nikolic B., Clinically Intelligent Diagnostic Devices and Methods, Patent Number US7622250.

7. Jacobs A. A., Gupta V. and Nikolic B., Devices and methods for diagnosis of susceptibility to diseases and disorders, Patent Number US7998679.

8. Gupta V. and Arnaout M. A. Compounds for Modulating Integrin CD11b/CD18. Patent Number US8268816.

9. Gupta V. and Werner M. H., Methods for Preparing Quantities of Preselected Polynucleotide Sequences and Uses Thereof, WO/2001/006017. Download file.

10. Jacobs A. A., Gupta V. and Nikolic B., Clinically Intelligent Diagnostic Devices and Methods, Patent Pending US2002/0095073. Download file.

11. Jacobs A. A., Gupta V. and Nikolic B., Clinically Intelligent Diagnostic Devices and Methods,WO/2002/042775. Download file.

12. Luehrsen K. R., Gupta V. et al., P450 Single Nucleotide Polymorphism Biochip Analysis. WO/2002/083839. Download file.

13. Brush, C.K. and Gupta V., Post-Synthetic Labeling of Nucleic Acids, Assays Using Nucleic Acids that are Labeled Post-Synthetically, Single Nucleotide Polymorphism Detection, and Associated Compounds and Microarrays, Patent Pending US2003/0119005. Download file.

14. Jacobs A. A., Gupta V. and Nikolic B., Methods and Devices for Detecting Hydrocarbons and petroleum products, WO/2003/012390. Download file.

15. Brush, C.K. and Gupta V., Post-Synthetic Labeling of Nucleic Acids and uses thereof,WO/2003/052115. Download file.

16. Xia, J. and Gupta V. et al., Compositions and Methods for Rolling Circle Amplification, Patent Pending US2004/0014078. Download file.

17. Jacobs A. A., Gupta V. and Nikolic B., Clinically Intelligent Diagnostic Devices and Methods, Patent Pending US2005/0191694. Download file.

18. Gupta V., Nikolic B. and Gupta V., Water-based personal moisturizers and lubricants, in particular vaginal lubricants, and uses thereof, Patent Pending US2006/0204557. Download file.

19. Vibha Gupta, Boris Nikolic and Vineet Gupta. Water-based personal moisturizers and lubricants, in particular vaginal lubricants, and uses thereof. Patent Pending, US2006/0204557.

20. Jacobs A. A., Gupta V. and Nikolic B., Clinically Intelligent Diagnostic Devices and Methods, Patent Pending US2006/0240453. Download file.

21. Gupta V. and Arnaout M. A. Compounds for Modulating Integrin CD11b/CD18. Patent Number US8268816.

22. Gupta V. Compounds and methods for regulating integrins. Patent Pending US20120010255.

23. Gupta V. and Arnaout M. A. Compounds for Modulating Integrin CD11b/CD18. Patent Pending US20130045967.

Leave a Reply

Your email address will not be published. Required fields are marked *