{"id":11,"date":"2022-04-23T20:05:24","date_gmt":"2022-04-23T20:05:24","guid":{"rendered":"https:\/\/guptalab.com\/?page_id=11"},"modified":"2023-10-25T02:09:20","modified_gmt":"2023-10-25T02:09:20","slug":"publications","status":"publish","type":"page","link":"https:\/\/guptalab.com\/index.php\/publications\/","title":{"rendered":"Publications"},"content":{"rendered":"\n
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Published Articles<\/h2>\n\n\n\n

56. <\/strong>Xiuting Liu, Graham D Hogg, Chong Zuo, Nicholas C Borcherding, John M Baer, Varintra E Lander, Liang-I Kang, Brett L Knolhoff, Faiz Ahmad, Robin E Osterhout, Anna V Galkin, Jean-Marie Bruey, Laura L Carter, Cedric Mpoy, Kiran R Vij, Ryan C Fields, Julie K Schwarz, Haeseong Park, Vineet Gupta, David G DeNardo, Context-dependent activation of STING-interferon signaling by CD11b agonists enhances anti-tumor immunity<\/strong>, Cancer Cell, 2023.<\/em><\/strong> DOI:10.1016\/j.ccell.2023.04.018<\/p>\n\n\n\n

55. <\/strong>Xiaobo Li, Ishwarya Venkatesh, Huiting Wei, Terese Geraghty, Anugraha Rajagopalan, Veronica Villanueva, Richard Helmuth, Mehmet Mete Altintas, Hafeez M Faridi,Vineet Gupta, Podocyte-specific deletion of miR-146a increases podocyte injury and diabetic kidney disease<\/strong>, Front. Med. Nephrology, 2022.<\/em><\/strong> DOI: 10.3389\/fmed.2022.897188<\/p>\n\n\n\n

54.<\/strong> V Villanueva, X Li, V Jimenez, H Faridi, V Gupta, CD11b agonists offer a novel approach for treating lupus nephritis,<\/strong> Translational Research, 2022<\/strong>.<\/em><\/p>\n\n\n\n

53. <\/strong>Xiuting Liu, Graham D Hogg, John M Baer, Varintra E Lander, Liang Kang, Nicholas C Borcherding, Brett L Knolhoff, Robin E Osterhout, Anna V Galkin, Jean Marie Bruey, Laura L Carter, Cedric Mpoy, Julie K Schwarz, Haeseong Park, Vineet Gupta, David DeNardo, Context-dependent triggering of STING-interferon signaling by CD11b agonists supports anti-tumor immunity in mouse models and human cancer patients<\/strong>, bioRxiv, 2022<\/em><\/strong>.<\/p>\n\n\n\n

52. <\/strong>Ateeq M. Khaliq, Cihat Erdogan, Zeyneb Kurt, Sultan Sevgi Turgut, Miles W. Grunvald, Tim Rand, Sonal Khare, Jeffrey A. Borgia, Dana M. Hayden, Sam G. Pappas, Henry R. Govekar, Audrey E. Kam, Jochen Reiser, Kiran Turaga, Milan Radovich, Yong Zang, Yingjie Qiu, Yunlong Liu, Melissa L. Fishel, Anita Turk, Vineet Gupta, Ram Al-Sabti, Janakiraman Subramanian, Timothy M. Kuzel, Anguraj Sadanandam, Levi Waldron, Arif Hussain, Mohammad Saleem, Bassel El-Rayes, Ameen A. Salahudeen & Ashiq Masood, Refining colorectal cancer classification and clinical stratification through a single-cell atlas,<\/strong> Genome Biology 2<\/em>022<\/strong>, 23.<\/p>\n\n\n\n

51. <\/strong>Kamalika Mukherjee, Changkyu Gu, Agnieszka Collins, Marcel Mettlen, Beata Samelko, Mehmet M Altintas, Yashwanth R Sudhini, Xuexiang Wang, Richard Bouley, Dennis Brown, Bradley P Pedro, Susan L Bane, Vineet Gupta, Paul T Brinkkoetter, Henning Hagmann, Jochen Reiser, Sanja Sever, Simultaneous stabilization of actin cytoskeleton in multiple nephron-specific cells protects the kidney from diverse injury<\/strong>, Nature Communications 2022<\/em><\/strong>, 13 (1), 1-14.<\/p>\n\n\n\n

50. <\/strong>Anugraha Rajagopalan, Ishwarya Venkatesh, Rabail Aslam, David Kirchenbuechler, Shreyaa Khanna, David Cimbaluk, Jeffrey H. Kordower, and Vineet Gupta, SeqStain using fluorescent-DNA conjugated antibodies allows efficient, multiplexed, spatialomic profiling of human and murine tissues, Cell Reports Methods 2021<\/em><\/strong>, June.<\/p>\n\n\n\n

49. <\/strong>Laisel Martinez, Xiaobo Li, Gioser Ramos-Echazabal, Hafeez Faridi, Zachary M. Zigmond, Nieves Santos Falcon, Diana R. Hernandez, Serene A. Shehadeh, Omaida C. Velazquez, Vineet Gupta* and Roberto I. Vazquez-Padron*, A Genetic Model of Constitutively Active Integrin CD11b\/CD18,<\/strong> Journal of Immunology, Nov 2020<\/em><\/strong>. PMID: 32938725. Cover Feature<\/strong>. <\/p>\n\n\n\n

48. <\/strong>Geraghty T, Rajagopalan A, Aslam R, Pohlman A, Venkatesh I, Zloza A, Cimbaluk D, DeNardo DG, and Gupta V., Positive Allosteric Modulation of CD11b as a Novel Therapeutic Strategy Against Lung Cancer<\/strong>, Front Oncol. 2020<\/strong> <\/em>May 21;10:748. doi: 10.3389\/fonc.2020.00748. eCollection 2020. PMID: 32528880.<\/p>\n\n\n\n

47. <\/strong>Newman JH, Chesson CB, Herzog NL, Bommareddy PK, Aspromonte SM, Pepe R, Estupinian R, Aboelatta MM, Buddhadev S, Tarabichi S, Lee M, Li S, Medina DJ, Giurini EF, Gupta KH, Guevara-Aleman G, Rossi M, Nowicki C, Abed A, Goldufsky JW, Broucek JR, Redondo RE, Rotter D, Jhawar SR, Wang SJ, Kohlhapp FJ, Kaufman HL, Thomas PG, Gupta V, Kuzel TM, Reiser J, Paras J, Kane MP, Singer EA, Malhotra J, Denzin LK, Sant’Angelo DB, Rabson AB, Lee LY, Lasfar A, Langenfeld J, Schenkel JM, Fidler MJ, Ruiz ES, Marzo AL, Rudra JS, Silk AW, Zloza A, Intratumoral injection of the seasonal flu shot converts immunologically cold tumors to hot and serves as an immunotherapy for cancer, Proc Natl Acad Sci U S A. 2020<\/em><\/strong> Jan 14;117(2):1119-1128. doi: 10.1073\/pnas.1904022116. Epub 2019 Dec 30. PMID: 31888983.<\/p>\n\n\n\n

46.<\/strong> Avasarala S, Wu PY, Khan SQ, Yanlin S, Van Scoyk M, Bao J, Di Lorenzo A, David O, Bedford MT, Gupta V, Winn RA, Bikkavilli RK, PRMT6 promotes lung tumor progression via the alternate activation of tumor-associated macrophages.<\/strong> Mol Cancer Res. 2020<\/em><\/strong> Jan;18(1):166-178. doi: 10.1158\/1541-7786.MCR-19-0204. Epub 2019 Oct 16. PMID: 31619507.<\/p>\n\n\n\n

45. <\/strong>Roheena Z Panni, John M Herndon, Chong Zuo, Samarth Hegde, Graham D Hogg, Brett L Knolhoff, Marcus A Breden, Xiaobo Li, Varintra E Krisnawan, Samia Q Khan, Julie K Schwarz, Buck E Rogers, Ryan C Fields, William G Hawkins, Vineet Gupta*, David G DeNardo<\/em>*, Agonism of CD11b reprograms innate immunity to sensitize pancreatic cancer to immunotherapies,<\/strong> Science Translational Medicine<\/strong> 2019<\/strong><\/em>, 03 Jul 2019, Vol. 11, Issue 499, eaau9240. DOI: 10.1126\/scitranslmed.aau9240. Cover Feature.<\/strong><\/p>\n\n\n\n

44. <\/strong><\/span>MC Schmid, SQ Khan, MM Kaneda, P Pathria, R Shepard, TL Louis, S Anand, G Woo, C Leem, MH Faridi, T Geraghty, A Rajagopalan, S Gupta, M Ahmed, RI Vazquez-Padron, DA Cheresh, V Gupta*<\/em><\/span> and JA Varner*<\/em>, Integrin CD11b activation drives anti-tumor innate immunity, <\/strong>Nature Communications 2018<\/em><\/strong><\/span> 9, 5379. DOI:10.1038\/s41467-018-07387-4.
Online link<\/a><\/p>\n\n\n\n

43. <\/strong>Catherine M Dickinson, Brian W LeBlanc, Muhammad M Edhi, Daithi S Heffernan, Mohd Hafeez Faridi, V Gupta<\/strong> William G Cioffi, Xian O\u2019Brien, Jonathan S Reichner, Leukadherin-1 ameliorates endothelial barrier damage mediated by neutrophils from critically ill patients, Journal of intensive care 2018<\/strong><\/em> 6, 19. DOI:10.1186\/s40560-018-0289-5.
Online link<\/a><\/p>\n\n\n\n

42. <\/strong>A Kaminski, KH Gupta, JW Goldufsky, HW Lee, Gupta V and SH Shafikhani, Pseudomonas aeruginosa ExoS Induces Intrinsic Apoptosis in Target Host Cells in a Manner That is Dependent on its GAP Domain Activity,<\/strong> Scientific reports 2018<\/strong><\/em> 8, 14047. DOI: 10.1038\/s41598-018-32491-2.
Online link<\/a><\/p>\n\n\n\n

41. <\/strong>Samia Q Khan, Imran Khan, and Gupta V, CD11b Activity Modulates Pathogenesis of Lupus Nephritis,<\/strong> Frontiers in medicine 2018<\/strong><\/em> 5, 52. DOI: 10.3389\/fmed.2018.00052.
Online link<\/a><\/p>\n\n\n\n

40. <\/strong>Ha Won Lee, Ehtesham Arif, Mehmet M Altintas, Kevin Quick, Shrey Maheshwari, Alexandra Plezia, Aqsa Mahmood, Jochen Reiser, Deepak Nihalani, and Gupta V, High-content screening assay-based discovery of paullones as novel podocyte-protective agents, <\/strong>American Journal of Physiology-Renal Physiology 2017<\/strong><\/em> 314, F280-F292. DOI: 10.1152\/ajprenal.00338.2017.
Online link<\/a><\/p>\n\n\n\n

39. <\/strong>Salim S Hayek, Kwi Hye Koh, Morgan E Grams, Changli Wei, Yi-An Ko, Jing Li, Beata Samelko, Hyun Lee, Ranadheer R Dande, Ha Won Lee, Eunsil Hahm, Vasil Peev, Melissa Tracy, Nicholas J Tardi,Gupta V, Mehmet M Altintas, Garrett Garborcauskas, Nikolina Stojanovic, Cheryl A Winkler, Michael S Lipkowitz, Adrienne Tin, Lesley A Inker, Andrew S Levey, Martin Zeier, Barry I Freedman, Jeffrey B Kopp, Karl Skorecki, Josef Coresh, Arshed A Quyyumi, Sanja Sever and Jochen Reiser, A tripartite complex of suPAR, APOL1 risk variants and \u03b1v\u03b23 integrin on podocytes mediates chronic kidney disease<\/strong>, Nature Medicine 2017<\/strong><\/em>, 23, 945. DOI: 10.1038\/nm.4362.
Online link<\/a><\/p>\n\n\n\n

38. <\/strong>Faridi MH, Khan SQ, Zhao W, Lee HW, Altintas MM, Zhang K, Kumar V, Armstrong AR, Carmona-Rivera C, Dorschner JM, Schnaith AM, Li X, Ghodke-Puranik Y, Moore E, Purmalek M, Irizarry-Caro J, Zhang T, Day R, Stoub D, Hoffmann V, Khaliqdina SJ, Bhargava P, Santander AM, Torroella-Kouri M, Issac B, Cimbaluk DJ, Zloza A, Prabhakar R, Deep S, Jolly M, Koh KH, Reichner JS, Bradshaw EM, Chen J, Moita LF, Yuen PS, Li Tsai W, Singh B, Reiser J, Nath SK, Niewold TB, Vazquez-Padron RI, Kaplan MJ and Gupta V, CD11b activation suppresses TLR-dependent inflammation and autoimmunity in systemic lupus erythematosus<\/strong>, J Clin Invest. 2017<\/strong><\/em>, Mar 6. DOI: 10.1172\/JCI88442.
Online link<\/a><\/p>\n\n\n\n

37. <\/strong>Hahm E, Wei C, Fernandez I, Li J, Tardi N, Tracy M, Wadhwani S, Cao Y, Peev V, Zloza A, Lusciks J, Hayek SS, O\u2019Connor C, Bitzer M, Gupta V, Sanja Sever, David B Sykes, David T Scadden and Jochen Reiser, Bone marrow-derived immature myeloid cells are a main source of circulating suPAR contributing to proteinuric kidney disease,<\/strong> Nature Medicine 2017<\/strong><\/em>, 23, 100\u2013106. DOI: 10.1038\/nm.4242.
Online link<\/a><\/p>\n\n\n\n

36. <\/strong>Lee HW, Khan SQ, Khaliqdina S, Altintas MM, Grahammer F, Zhao JL, Koh K, Tardi NJ, Faridi MH, Geraghty T, Cimbaluk DJ, Susztak K, Moita LF, Baltimore D, Tharaux PL, Huber TB, Kretzler M, Bitzer M, Reiser J and <\/strong>Gupta V, Absence of miR-146a in podocytes increases risk of diabetic glomerulopathy via upregulation of erbb4 and notch-1,<\/strong> J Biol Chem. 2016<\/strong><\/em> Dec 2. PMID: 27913625. DOI: 10.1074\/jbc.M116.753822.
Online link<\/a><\/p>\n\n\n\n

35. <\/strong>Johnson CM, O\u2019Brien XM, Byrd AS, Parisi VE, Loosely AJ, Li W, Witt H, Faridi HM, Lefort CT, Gupta V, Kim M, and Reichner JS, Integrin Cross-Talk Regulates the Human Neutrophil Response to Fungal \u03b2-Glucan in the Context of the Extracellular Matrix: A Prominent Role for VLA3 in the Antifungal Response, <\/strong>J Immunol. 2016<\/strong><\/em> Nov 16. PMID: 27852744. DOI: 10.4049\/jimmunol.1502381.
Online link<\/a><\/p>\n\n\n\n

34. <\/strong>Gupta V, and Reiser J, Stop that podocyte!<\/strong> American Journal of Physiology-Renal Physiology. 2016<\/strong><\/em> Oct 19. PMID: 27760773. DOI: 10.1152\/ajprenal.00499.2016.
Online link<\/a><\/p>\n\n\n\n

33. <\/strong>Gu C, Lee HW, Garborcauskas G, Reiser J, Gupta V, and Sever S, Dynamin Autonomously Regulates Podocyte Focal Adhesion Maturation<\/strong>, Journal of the American Society of Nephrology. 2016<\/strong><\/em> Jul 18. PMID: 27432739. DOI: 10.1681\/ASN.2016010008.
Online link<\/a><\/p>\n\n\n\n

32. <\/strong>Jagarapu J, Kelchtermans J, Rong M, Chen S, Hehre D, Hummler S, Faridi MH, Gupta V, and Wu, S, Leukadherin-1 Attenuates Hyperoxia-induced Lung Injury in Neonatal Rats,<\/strong> Am J Respir Cell Mol Biol. 2015<\/strong><\/em> Apr 24. [Epub ahead of print]. PMID: 25909334. DOI: 10.1165\/rcmb.2014-0422OC.
Online link<\/a><\/p>\n\n\n\n

31. <\/strong>Lee HW, Khan SQ, Faridi MH, Wei C, Tardi NJ, Altintas MM, Elshabrawy HA, Mangos S, Quick KL, Sever S, Reiser J and Gupta V, A Podocyte-Based Automated Screening Assay Identifies Protective Small Molecules,<\/strong> Journal of the American Society of Nephrology. 2015<\/strong><\/em> Apr 9, 2015. pii: ASN.2014090859. [Epub ahead of print]. PMID: 25858967. doi: 10.1681\/ASN.2014090859.
Online link<\/a><\/p>\n\n\n\n

30. <\/strong>Khan SQ, Guo L, Cimbaluk DJ, Elshabrawy H, Faridi MH, Jolly M, George JF, Agarwal A and Gupta V, A Small Molecule \u03b22 Integrin Agonist Improves Chronic Kidney Allograft Survival by Reducing Leukocyte Recruitment and Accompanying Vasculopathy,<\/strong> Front. Med., 2014<\/strong><\/em> 12 Nov 2014. doi: 10.3389\/fmed.2014.00045
Online link<\/a><\/p>\n\n\n\n

29. <\/strong>Gupta V and Reiser J, MicroRNAs: A Macroview Into Focal Segmental Glomerulosclerosis<\/strong>,  Am J Kidney Dis.<\/strong><\/em> 2015 Feb;65(2):206-8. doi:10.1053\/j.ajkd.2014.11.003
Online link<\/a><\/p>\n\n\n\n

28. <\/strong>Rodriguez-Menocal L, Faridi MH, Martinez L, Shehadeh LA, Duque JC, Wei Y, Mesa A, Pena A, Gupta V, Pham SM and Vazquez-Padron RI, Macrophage-derived IL-18 and increased fibrinogen deposition are age-related inflammatory signatures of vascular remodeling<\/strong>, American Journal of Physiology \u2013 Heart and Circulatory Physiology, 2014<\/strong><\/em> March 2014, Vol. 306, no. 5, H641-H653. doi:10.1152\/ajpheart.00641.2013.
Online link<\/a><\/p>\n\n\n\n

27. <\/strong>Casc\u00e3o R, Vidal B, Raquel H, Neves-Costa A, Figueiredo N, Gupta V, Fonseca JE and Moita LF, Potent Anti-Inflammatory and Anti-Proliferative Effects of Gambogic Acid in a Rat Model of Antigen-Induced Arthritis,<\/strong> Mediators of Inflammation, 2014<\/strong><\/em> Jan, Volume 2014 (2014), Article ID 195327. doi:10.1155\/2014\/195327
Online link<\/a><\/p>\n\n\n\n

26. <\/strong>Celik E, Faridi MH, Kumar V, Deep S, Moy VT and Gupta V, Agonist leukadherin-1 increases CD11b\/CD18 dependent adhesion via membrane tethers, <\/strong>Biophysical Journal, 2013<\/strong><\/em> Dec, Volume 105, Issue 11, 2517-2527. doi:10.1016\/j.bpj.2013.10.020.
Online link<\/a><\/p>\n\n\n\n

25. <\/strong>Weston W, Gupta V, Adkins R, Jurecic R, New therapeutic approaches for protecting hematopoietic stem cells in aplastic anemia, <\/strong>Immunol Res, 2013<\/strong><\/em> Dec;57(1-3):34-43. doi:10.1007\/s12026-013-8449-0.
Online link<\/a><\/p>\n\n\n\n

24. <\/strong>Figueiredo N, Chora A, Raquel H, Pejanovic N, Pereira P, Hartleben B, Neves-Costa A, Moita C, Pedroso D, Pinto A, Marques S, Faridi H, Costa P, Gozzelino R, Zhao JL, Soares MP, Gama-Carvalho M, Martinez J, Zhang Q, D\u00f6ring G, Grompe M, Simas JP, Huber TB, Baltimore D, Gupta V, Green DR, Farreira JA, Moita LF, Anthracyclins induce autophagy-mediated protection from severe sepsis,<\/strong> Immunity, 2013<\/strong><\/em> Nov 14;39(5):874-84. doi:10.1016\/j.immuni.2013.08.039.
Online link<\/a><\/p>\n\n\n\n

23. <\/strong>Yu CC, Fornoni A, Weins A, Hakroush S, Maiguel D, Sageshima J, Chen L, Ciancio G, Faridi MH, Behr D, Campbell KN, Chang JM, Chen HC,Oh J, Faul C, Arnaout MA, Fiorina P, Gupta V, Greka A, Burke G, Mundel P, Abatacept in B7-1 Positive Proteinuric Kidney Disease,<\/strong> New England Journal of Medicine, 2013<\/strong><\/em> Nov 8. doi:10.1056\/NEJMoa1304572.
Online link<\/a><\/p>\n\n\n\n

22. <\/strong>Bhat V, Olenick MB, Schuchardt BJ, Mikles DC, Deegan BJ, McDonald CB, Seldeen KL, Kurouski D, Faridi MH, Shareef MM, Gupta V, Lednev IK, Farooq A, Heat-induced fibrillation of BclXL apoptotic repressor, <\/strong>Biophys Chem, 2013<\/strong><\/em> Sep;179:12-25. doi: 10.1016\/j.bpc.2013.04.002.
Online link<\/a><\/p>\n\n\n\n

21. <\/strong>Faridi MH, Altintas MM, Gomez C, Duque JC, Vazquez-Padron RI, Gupta V, Small molecule agonists of integrin CD11b\/CD18 do not induce global conformational changes and are significantly better than activating antibodies in reducing vascular injury,<\/strong> Biochimica et Biophysica Acta, 2013<\/strong><\/em> Jun;1830(6):3696-710. doi: 10.1016\/j.bbagen.2013.02.018.
Online link<\/a><\/p>\n\n\n\n

20. <\/strong>Reed RH, Jain M, Lee K, Kandimalla ER, Faridi MH, Buyon JP, Gupta V, Clancy RM, Complement receptor 3 influences Toll-like receptor 7\/8 dependent inflammation: implications for autoimmune diseases characterized by antibody reactivity to ribonucleoproteins<\/strong>, J Biol Chem, 2013<\/strong><\/em>. Mar 29;288(13):9077-83. doi: 10.1074\/jbc.M112.403303.
Online link<\/a><\/p>\n\n\n\n

19. <\/strong>Casc\u00e3o R, Vidal B, Raquel H, Neves-Costa A, Figueiredo N, Gupta V, Fonseca JE, Moita LF, Effective treatment of rat adjuvant-induced arthritis by celastrol,<\/strong> Autoimmun Rev, 2012<\/strong><\/em>. Oct;11(12):856-62. doi: 10.1016\/j.autrev.2012.02.022. Epub 2012 Mar 3.<\/p>\n\n\n\n

18.<\/strong> Maiguel D, Faridi MH, Wei C, Kuwano Y, Balla KM, Hernandez D, Barth CJ, Lugo G, Donnelly M, Nayer A, Moita LF, Sch\u00fcrer S, Traver D, Ruiz P, Vazquez-Padron RI, Ley K, Reiser J, Gupta V, Small molecule-mediated activation of the integrin CD11b\/CD18 reduces inflammatory disease<\/strong>, Science Signaling<\/em><\/strong>, 2011<\/strong> Sep 6;4(189):ra57. PMID: 21900205
Article link<\/a><\/p>\n\n\n\n

This work was featured in a Highlight in Nature Reviews in Immunology<\/strong>, 11, 638 (October 2011) and in a Highlight in Acta Pharmacologica Sinica<\/strong> (2011) 32: 1309\u20131310.<\/p><\/blockquote>\n\n\n\n

17<\/strong>. Wei C, El Hindi S, Li J, Fornoni A, Goes N, Sageshima J, Maiguel D, Karumanchi SA, Yap HK, Saleem M, Zhang Q, Nikolic B, Chaudhuri A, Daftarian P, Salido E, Torres A, Salifu M, Sarwal MM, Schaefer F, Morath C, Schwenger V, Zeier M, Gupta V, Roth D, Rastaldi MP, Burke G, Ruiz P, Reiser J., Circulating urokinase receptor as a cause of focal segmental glomerulosclerosis.<\/strong> Nature Medicine<\/em>, 2011 <\/strong>Jul 31;17(8):952-60. doi: 10.1038\/nm.2411. PMID: 21804539
Online link<\/a><\/p>\n\n\n\n

This work was featured as a Cover article and in a Highlight in the same issue of Nature Medicine<\/strong>.<\/p><\/blockquote>\n\n\n\n

16.<\/strong> Faridi MH, Maiguel D, Brown BT, Suyama E, Barth CJ, Hedrick M, Vasile S, Sergienko E, Sch\u00fcrer S, Gupta V, High-throughput screening based identification of small molecule antagonists of integrin CD11b\/CD18 ligand binding<\/strong>, Biochem Biophys Res Commun<\/em>, 2010<\/strong>, Mar 26;394(1):194-9. Epub 2010 Feb 25. PMID: 20188705.
File link<\/a><\/p>\n\n\n\n

15.<\/strong> Reiser J, Gupta V<\/strong>, Kistler AD. Toward the development of podocyte-specific drugs<\/strong>, Kidney International<\/em> 2010<\/strong> Apr;77(8):662-8. Epub 2010 Feb 3. PMID: 20130528. Online link<\/a><\/p>\n\n\n\n

14.<\/strong> Faridi MH, Maiguel D, Barth CJ, Stoub D, Day R, Sch\u00fcrer S, Gupta V, Identification of novel agonists of the integrin CD11b\/CD18, Bioorg Med Chem Lett<\/em>, 2009<\/strong> Dec 15;19(24):6902. NIHMS154324. File link<\/a><\/p>\n\n\n\n

13.<\/strong> Qureshi AH, Chaoji V, Maiguel D, Faridi MH, Barth CJ, Salem SM, Singhal M, Stoub D, Krastins B, Ogihara M, Zaki MJ, Gupta V, Proteomic and phospho-proteomic profile of human platelets in basal, resting state: insights into integrin signaling<\/strong>, PLoS One<\/em>, 2009<\/strong> Oct 27;4(1):e7627. File link<\/a><\/p>\n\n\n\n

12.<\/strong> Banerjee A., Sergienko E., Vasile S., Gupta V., Vuori K. and Wipf P., Triple Hybrids of Steroids, Spiroketals, and Oligopeptides as New Biomolecular Chimeras,<\/strong> Organic Letters<\/em>, 2009 <\/strong>Jan 1;11(1):65. File link<\/a><\/p>\n\n\n\n

11.<\/strong> Gupta V., Alonso J.-L., Sugimori T., Issafi M., Xiong J.-P. and Arnaout M. A., Role of the beta-subunit arginine\/lysine finger in integrin heterodimer formation and function, Journal of Immunology<\/em>, 2008<\/strong> Mar 1;180(5):3613. File link<\/a><\/p>\n\n\n\n

10.<\/strong> Wei C., M\u00f6ller C.C., Altintas M.M., Li J., Schwarz K., Zacchigna S., Xie L., Henger A., Schmid H., Rastaldi M.P., Cowan P., Kretzler M., Parrilla R., Bendayan M., Gupta V., Nikolic B., Kalluri R., Carmeliet P., Mundel P. and Reiser J., Modification of kidney barrier function by the urokinase receptor<\/strong>, Nature Medicine<\/em>, 2008<\/strong> Jan;14(1):55-63. Epub 2007 Dec 16. File link<\/a><\/p>\n\n\n\n

9.<\/strong> Park, J.Y., Arnaout, M.A. and Gupta V., A simple, no-wash cell-adhesion based high throughput assay for the discovery of small molecule regulators of the integrin CD11b\/CD18<\/strong>, Journal of Biomolecular Screening<\/em>, 2007<\/strong> Apr;12(3):406-17. File link<\/a><\/p>\n\n\n\n

8.<\/strong> Gupta V., Gylling A., Alonso, J.-L., Sugimori T., Ianakiev, P., Xiong J.-P. and Arnaout M. A.,The \u03b2-tail domain (\u03b2TD) regulates physiologic ligand binding to integrin CD11b\/CD18<\/strong>, Blood<\/em>, 2007<\/strong> Apr 15;109(8):3513-20. Epub 2006 Dec 14 (DOI 10.1182\/blood-2005-11-056689). File link<\/a><\/p>\n\n\n\n

This work was featured in a Highlight in the same issue of Blood<\/strong>.<\/p><\/blockquote>\n\n\n\n

7.<\/strong> Gupta* V., Cherkassky A., Chatis P., Joseph R., Johnson A. J., Erickson T. and Dimeo J., Directly labeled mRNA produces highly precise and unbiased differential gene expression data, Nucleic Acids Research<\/em>, 2003<\/strong>, 31, e13. File link<\/a><\/p>\n\n\n\n

6.<\/strong> Werner MH, Nagata T, Gupta V, Goger M, Chait BT, S\u00e2li A, Kim WY, Shigesada K, Ito Y. Molecular insights into the origin of the acute human leukemias revealed from the three-dimensional structure and sub-cellular localization of AML1,<\/strong> Clinical Cancer Res<\/em>, 1999<\/strong>, 5, 3780S.<\/p>\n\n\n\n

5.<\/strong> Werner M. H., Gupta V., Lambert L.J. and Nagata T., Uniform 13C\/15N-labeling of DNA by tandem repeat amplification,<\/strong> Methods in Enzymology<\/em>, 2001<\/strong>, 338, 283-304. File link<\/a><\/p>\n\n\n\n

4.<\/strong> Nagata* T., Gupta* V., Sorce D., Kim W-Y., S\u00e2li A., Chait B. T., Shigesada K., Ito Y. and Werner M. H., Immunoglobulin-motif DNA recognition and heterodimerization for the PEBP2\/CBF Runt-domain, Nature Structural Biology<\/em>, 1999<\/strong>, 615-619. File link<\/a><\/p>\n\n\n\n

3. <\/strong>Goger* M., Gupta* V., Kim W-Y., Shigesada K., Ito Y. and Werner M. H. , Molecular insights into PEBP2\/CBF-SMMHC associated acute leukemias revealed from the three-dimensional structure of PEBP2\/CBF beta,<\/strong> Nature Structural Biology<\/em>, 1999<\/strong>, 620-623. File link<\/a><\/p>\n\n\n\n

2. <\/strong>Gupta V. and Kool E. T. A Novel Self-Cleaving DNA Nucleoside, Chemical Communications<\/em>, 1997<\/strong>, 1425-26. File link<\/a><\/p>\n\n\n\n

1.<\/strong> Jayaram B., Aneja N., Rajsekaran E., Arora V., Das A., Ranganathan V. and Gupta V., Modeling DNA in Aqueous Solution, Journal of Scientific and Industrial Research<\/em>, 1994<\/strong>, 53 (2), 88-105.<\/p>\n\n\n\n

..<\/p>\n\n\n\n

Others Publications<\/strong><\/p>\n\n\n\n

8.<\/strong> Cheng, Q., Ogihara, M., and Gupta, V., Learning condition-dependent dynamical PPI networks from conflict-sensitive phosphorylation dynamics,<\/strong> In Proceedings of the IEEE Conference on Biomedicine and Computational Biology (IEEE-BIBM)<\/em>, 2011<\/strong>. B459. Online link<\/a><\/p>\n\n\n\n

7.<\/strong> Jain, Manish, Amato, Michael, Buyon, Jill P., Gupta V, Clancy, Robert M.; A Novel CR3 Agonist Attenuates Pro-Inflammatory Signaling in Subjects with Common and Variant ITGAM Polymorphism, rs1143679.<\/strong> Arthritis Rheum<\/strong><\/em> 2011<\/strong>;63 Suppl 10 :1675.<\/p>\n\n\n\n

6.<\/strong> Casc\u00e3o R, Vidal B, Raquel H, Neves-Costa A, Figueiredo N, Gupta V, Fonseca JE, Moita LF. Drugs that simultaneously down-regulate IL-1b and TNF secretion significantly reduce inflammation in a rat model of antigen-induced arthritis<\/strong>, Journal of Translational Medicine<\/strong><\/em> 2011<\/strong>, 9(Suppl 2):P21.<\/p>\n\n\n\n

5.<\/strong> Cheng, Q., Gupta, V., and Ogihara, M., Inferring conflicting phosphorylation dynamics,<\/strong> In Proceedings of the ACM Conference on Computational Biology and Biomedicine (ACM-BCB)<\/em>, 2011<\/strong>. Online link<\/a><\/p>\n\n\n\n

4.<\/strong> Dony Maiguel; Mohd Hafeez Faridi; Roberto Vazquez-Padron; Vineet Gupta Novel Small Molecule Agonists of Integrin Cd11b\/cd18 Reduce Leukocyte Migration and Post Injury Neointimal Hyperplasia<\/strong>, Circulation<\/strong> <\/em>2010<\/strong>; 122: A16106.<\/p>\n\n\n\n

3.<\/strong> Gupta V., Parthasarathsy S. and Zaki M. J., Arithmetic and Logic Operations with DNA<\/strong>, Proceedings of the 3rd DIMACS Workshop on DNA Based Computers<\/em> 1997<\/strong>, 212-220. File link<\/a><\/p>\n\n\n\n

2.<\/strong> Gupta V. Studies Aimed at Controlled Chemical Cleavage of DNA<\/strong>. Thesis<\/em>, 1997 <\/strong>University Of Rochester, 1997.<\/p>\n\n\n\n

1.<\/strong> Gupta V. Computer Modeling and Theoretical Studies of Drug-DNA Interactions. <\/strong>Thesis<\/strong><\/em>, 1992<\/strong> Indian institute of Technology, Delhi; 1992<\/strong>.<\/p>\n\n\n\n

..<\/p>\n\n\n\n

Published Patents and Patent Applications<\/strong><\/p>\n\n\n\n

1.<\/strong> Gupta V. and Werner M. H., Methods for Preparing Polynucleotide Sequences and Uses Thereof, Patent number US6194179<\/strong>, 2001. Download file<\/a>.<\/p>\n\n\n\n

2.<\/strong> Jacobs A. A., Gupta V. and Nikolic B., Clinically Intelligent Diagnostic Devices and Methods, Patent number US6905816<\/strong>. Download file<\/a>.<\/p>\n\n\n\n

3.<\/strong> Chui B., Elghanian R. E., Gupta V. et al., P450 Single Nucleotide Polymorphism Biochip Analysis, Patent Number US6986992<\/strong>. Download file<\/a>.<\/p>\n\n\n\n

4.<\/strong> Brush, C.K. and Gupta V., Post-Synthetic Labeling of Nucleic Acids, Assays Using Nucleic Acids that are Labeled Post-Synthetically, Single Nucleotide Polymorphism Detection, and Associated Compounds and Microarrays, Patent Number US7223538<\/strong>.<\/p>\n\n\n\n

5.<\/strong> Jacobs A. A., Gupta V. and Nikolic B., Clinically Intelligent Diagnostic Devices and Methods, Patent Number US7566533<\/strong>.<\/p>\n\n\n\n

6. <\/strong>Jacobs A. A., Gupta V. and Nikolic B., Clinically Intelligent Diagnostic Devices and Methods, Patent Number US7622250<\/strong>.<\/p>\n\n\n\n

7.<\/strong> Jacobs A. A., Gupta V. and Nikolic B., Devices and methods for diagnosis of susceptibility to diseases and disorders, Patent Number US7998679<\/strong>.<\/p>\n\n\n\n

8. <\/strong>Gupta V. and Arnaout M. A. Compounds for Modulating Integrin CD11b\/CD18. Patent Number US8268816<\/strong>.<\/p>\n\n\n\n

9.<\/strong> Gupta V. and Werner M. H., Methods for Preparing Quantities of Preselected Polynucleotide Sequences and Uses Thereof, WO\/2001\/006017<\/strong>. Download file<\/a>.<\/p>\n\n\n\n

10.<\/strong> Jacobs A. A., Gupta V. and Nikolic B., Clinically Intelligent Diagnostic Devices and Methods, Patent Pending US2002\/0095073<\/strong>. Download file<\/a>.<\/p>\n\n\n\n

11.<\/strong> Jacobs A. A., Gupta V. and Nikolic B., Clinically Intelligent Diagnostic Devices and Methods,WO\/2002\/042775<\/strong>. Download file<\/a>.<\/p>\n\n\n\n

12.<\/strong> Luehrsen K. R., Gupta V. et al., P450 Single Nucleotide Polymorphism Biochip Analysis. WO\/2002\/083839<\/strong>. Download file<\/a>.<\/p>\n\n\n\n

13.<\/strong> Brush, C.K. and Gupta V., Post-Synthetic Labeling of Nucleic Acids, Assays Using Nucleic Acids that are Labeled Post-Synthetically, Single Nucleotide Polymorphism Detection, and Associated Compounds and Microarrays, Patent Pending US2003\/0119005<\/strong>. Download file<\/a>.<\/p>\n\n\n\n

14.<\/strong> Jacobs A. A., Gupta V. and Nikolic B., Methods and Devices for Detecting Hydrocarbons and petroleum products, WO\/2003\/012390<\/strong>. Download file<\/a>.<\/p>\n\n\n\n

15.<\/strong> Brush, C.K. and Gupta V., Post-Synthetic Labeling of Nucleic Acids and uses thereof,WO\/2003\/052115<\/strong>. Download file<\/a>.<\/p>\n\n\n\n

16.<\/strong> Xia, J. and Gupta V. et al., Compositions and Methods for Rolling Circle Amplification, Patent Pending US2004\/0014078<\/strong>. Download file<\/a>.<\/p>\n\n\n\n

17.<\/strong> Jacobs A. A., Gupta V. and Nikolic B., Clinically Intelligent Diagnostic Devices and Methods, Patent Pending US2005\/0191694<\/strong>. Download file<\/a>.<\/p>\n\n\n\n

18.<\/strong> Gupta V., Nikolic B. and Gupta V., Water-based personal moisturizers and lubricants, in particular vaginal lubricants, and uses thereof, Patent Pending US2006\/0204557<\/strong>. Download file<\/a>.<\/p>\n\n\n\n

19.<\/strong> Vibha Gupta, Boris Nikolic and Vineet Gupta. Water-based personal moisturizers and lubricants, in particular vaginal lubricants, and uses thereof. Patent Pending, US2006\/0204557<\/strong>.<\/p>\n\n\n\n

20.<\/strong> Jacobs A. A., Gupta V. and Nikolic B., Clinically Intelligent Diagnostic Devices and Methods, Patent Pending US2006\/0240453<\/strong>. Download file<\/a>.<\/p>\n\n\n\n

21. <\/strong>Gupta V. and Arnaout M. A. Compounds for Modulating Integrin CD11b\/CD18. Patent Number US8268816<\/strong>.<\/p>\n\n\n\n

22.<\/strong> Gupta V. Compounds and methods for regulating integrins. Patent Pending US20120010255<\/strong>.<\/p>\n\n\n\n

23. <\/strong>Gupta V. and Arnaout M. A. Compounds for Modulating Integrin CD11b\/CD18. Patent Pending US20130045967<\/strong>.<\/p>\n<\/div>\n\n\n\n

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Google Scholar<\/a><\/div>\n<\/div>\n<\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

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